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Pathology of hives

Submitted by admin on Tue, 11/23/2021 - 00:13

Current treatments are based on preventing mast cells from being activated or neutralising the chemicals that are released by these cells.1

  • Urticaria pathology, sometimes called urticaria pathophysiology, explains how symptoms occur.
  • Mast cells occur in areas of the body that are in contact with their surroundings – e.g. skin and mucous membranes.2
  • When they detect threats such as invading bacteria or parasites they become activated and release histamine and leukotriene messengers. They provide warning signals to alert your body to remove the threat.2
  • In urticaria your immune system makes a mistake. The mast cells become activated when there is no real threat at all. But consequences are all too real. The signals released by the activated mast cells irritate nerve endings in the skin resulting in itch and they can also cause nearby blood vessels to swell and leak which causes redness and swelling.2
  • When the cause or trigger of the hives is unknown, treatment involves preventing the mast cells from being activated and/or reducing the amount of chemicals such as histamines and leukotrienes released by the mast cells.1
There are treatments for hives. Speak to your doctor about the best treatment for you.SYMPTOM CHECKER

 

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Urticaria (hives) treatment options What are the treatment options for chronic hives people? Can a healthy diet help manage chronic urticaria?

 

References

  • Vestergaard C and Deleuran M. Ther Adv Chron Dis 2015; 6:304–313.
  • Urb M and Sheppard DC. PLoS Pathog 2012; 8:e1002619.
 
 
 
 
 
There are effective treatments for hives and itch. For some of these treatments you need to be in the care of an immunologist or dermatologist.

Speak to your GP about a referral to an urticaria specialist.
 
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